ABOUT US
Our Mission is to make outsourcing strain development the new norm for companies and academics alike.
The Synthetic Biology Research Centre, based at the University of Nottingham, specialised in difficult-to-engineer industrially important and medically significant bacteria. Transforming many species was difficult or impossible, and using CRISPR caused additional problems for DNA transfer and modification of the target organism.
To solve these problems, Forge Editing was invented. This technique uses no CRISPR proteins whatsoever, but still benefits from the reprogrammability allowed by an RNA targeting region.
Forge Genetics was spun-out to commercialise this technique - offering strain development and licensing opportunities for Forge Editing technology.
Since developing Forge Editing, we have demonstrated the technique in 6 different bacterial species, comprising Clostridium, Escherichia, Staphylococcus and Bacillus, with 30+ individual knockouts and 10+ heterologous insertion strains.
Forge Editing technology bears the potential for wide scope of application across diverse biological systems.
