Our mission is to make outsourcing strain development the new norm for companies and academics alike.
The Synthetic Biology Research Centre, based at the University of Nottingham, worked with difficult-to-engineer industrially useful or medically significant bacterial species. Transforming many species was difficult or impossible, and using CRISPR caused additional problems for DNA transfer, and failed to reliably make edits.
To solve these problems, “Forge Editing” was invented. This technique uses no CRISPR proteins whatsoever, but still benefits from the reprogrammability allowed by an RNA targeting region.
Forge Genetics was spun-out to commercialise this technique — offering strain development and licensing opportunities for the technology.
Since developing the technology, we have demonstrated the technique in 6 different bacterial species, comprising Clostridium, Escherichia, Staphylococcus, and Bacillus, with 30+ individual knockouts and 10+ heterologous insertion strains.